Stiatistical Issues in Meta-Analysis
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Title
Stiatistical Issues in Meta-Analysis
Author
Xu , Dihua
Advisors
Sinha , Bimal K ; Knapp , Guido
Program
Statistics
UMBC Department
Mathematics and Statistics
Document Type
dissertation
Sponsors
University of Maryland , Baltimore County (UMBC)
Keywords
Adverse Event ; Bootstrap ; Cochran's test ; Correlation Matrics ; Homogeneity test ; Meta-Analysis
Date Issued
2011-01-01
Abstract
In statistical meta-analysis paradigm dealing with the techniques of pooling of evidence across several studies , the notion of effect size is fundamental and it is necessary to perform appropriate tests for the equality of population effect sizes arising out of these studies before performing any meta-analysis . A well known test for homogeneity in this context is based on Cochran's chi-square statistic . However Cochran's test might be inaccurate in testing homogeneity for some effect sizes in the sense of not maintaining the stipulated Type I errors . In this dissertation , three such scenarios are identified : 1) testing homogeneity of standardized mean difference , 2) testing homogeneity of correlations and correlation matrices , and 3) testing homogeneity of proportions with low event rates , and in each case the severe inadequacy of Cochran's homogeneity test is demonstrated . Apppropriate bootstrap procedures for testing homogeneity hypotheses are suggested , and applications in each problem are indicated . Two additional problems are also dealt with in the dissertation : Mantel-Haenszel and Peto weights in random effects meta-analysis , and extraction methods in statistical meta-analysis .
Identifier
10448
Format
application:pdf
Language
en
Collection
UMBC Theses and Dissertations .
Rights Statement
This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://library.umbc.edu/speccoll/rightsreproductions.php or contact Special Collections at speccoll(at)umbc.edu.
Source
Xu_umbc_0434D_10448.pdf
Access Rights
Access limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.
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