STUDY OF THE MORPHOLOGY AND PHYSIOLOGY OF FILAMENTOUS FUNGI DURING NUTRIENT STARVATION USING THE PARALLEL PLATE FLOW CHAMBER

Title	STUDY OF THE MORPHOLOGY AND PHYSIOLOGY OF FILAMENTOUS FUNGI DURING NUTRIENT STARVATION USING THE PARALLEL PLATE FLOW CHAMBER
Author	Pollack, Judith Kadarusman
Advisors	Marten, Mark R.
Program	Chemical and Biochemical Engineering
UMBC Department	Chemical and Biochemical Engineering
Document Type	dissertation
Sponsors	University of Maryland, Baltimore County (UMBC)
Keywords	Engineering, Chemical(0542); nutrient starvation; morphology; autophagy; branching; Aspergillus
Date Issued	2008-08-21; *
Abstract	Filamentous fungi play important roles in health care, agriculture, and bioprocessing. In many situations, they experience nutrient starvation. In some cases, nutrient starvation detrimentally affects cellular morphology and physiology; in other cases, it can be beneficial. Thus, a better understanding of how starvation influences morphology may result in strategies to control morphology to our advantage. However, little is known about how individual fungal mycelia respond to nutrient starvation at the cellular and molecular level. For studies at the cellular level, we grew fungal mycelia in a parallel plate flow chamber, which allows for complete environmental control while monitoring individual mycelia over time. We discovered that the first response to carbon starvation is cessation of growth (i.e. lag time) before mycelia resume re-growth at a lower rate. During this lag time, vacuolation increases significantly, implying significant cellular restructuring and recycling. We propose a model in which the duration of the lag time is determined by the production rate of endogenous carbon and mycelial size. For studies at the molecular level, we investigated the role of autophagy using a strain of the model fungus <em>Aspergillus nidulans
Identifier	1186
Format	application:pdf
Language	en
Collection	UMBC Theses and Dissertations
Rights Statement	This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu.
Source	umi-umbc-1186.pdf

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STUDY OF THE MORPHOLOGY AND PHYSIOLOGY OF FILAMENTOUS FUNGI DURING NUTRIENT STARVATION USING THE PARALLEL PLATE FLOW CHAMBER

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