Multivalent Sialic Acid Polymers: A Novel Chemistry
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Title
Multivalent Sialic Acid Polymers : A Novel Chemistry
Author
Geisz Jr. , Anton Jeffrey
Advisors
Good , Theresa A.
Program
Engineering, Chemical and Biochemical
UMBC Department
Chemical and Biochemical Engineering
Document Type
thesis
Sponsors
University of Maryland , Baltimore County (UMBC)
Keywords
Engineering , Chemical (0542) ; Sialic Acid ; Alzheimer's Disease ; Polymerization ; Organic Phase Solubilization
Date Issued
2008-08-21 ;
Abstract
Alzheimer's Disease claims approximately 65,800 victims each year . At present , it is estimated that 4.5 million Americans and 26 million people world wide are believed to have Alzheimer's Disease . The research presented here is the development of a novel route of polymer synthesis whereby a biomimetic multivalent Sialic acid polymer is created for the competitive binding and toxicity attenuation of ?-amyloid , a major component of senile plaques associated with the disease . The chemistry makes use of an organic phase crosslinker attachment to a carbohydrate backbone , followed by an aqueous phase free radical photopolymerization . Proof of crosslinker attachment is presented as is a kinetic model of polymerization that is capable of determining appropriate rate constants for the polymerization based on the data that is being modeled . This work represents a first step in the design of new materials for the use in Alzheimer's disease .
Identifier
1230
Format
application:pdf
Language
en
Collection
UMBC Theses and Dissertations
Rights Statement
This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://library.umbc.edu/speccoll/rightsreproductions.php or contact Special Collections at speccoll(at)umbc.edu.
Source
umi-umbc-1230.pdf
Access Rights
Access limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.
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