Construction of a Dual Infection Mechanism for HIV
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Title
Construction of a Dual Infection Mechanism for HIV
Author
Piekarski , Joseph Matthew
Advisors
Castellanos , Mariajose
Program
Engineering, Chemical and Biochemical
UMBC Department
Chemical and Biochemical Engineering
Document Type
thesis
Sponsors
University of Maryland , Baltimore County (UMBC)
Keywords
Cell-to-Cell ; Dual Infection ; Dynamics ; HIV ; Mathematical Model ; T Cell
Date Issued
2009-01-01 ;
Abstract
In this work , we created three mathematical models to describe HIV infection . Our goal was to investigate the effectiveness of cell- to- cell infection via “ virological synapses” through the designed models . The combination of cell- to- cell infection and free- floating virus mechanisms in mathematical models has not been investigated as of yet . We evaluated the two models using three statistical techniques , and decided to use a weighted summation of squares to compare our projected results to published experimental data . The analysis found that the addition of a cell- to- cell infection mechanism did not hinder the predictability of HIV markers for disease progression and showed cell- to- cell infection was most significant early on in infection . In our last model , we further investigated the mechanisms responsible for T cell depletion . Many theories have been published hypothesizing the cause of immune failure . These range from heightened activation of T cells , cytotoxic virions and the eventual destruction due to productive infection . In our model , we observed that the majority of cells die due to the direct result of infection .
Identifier
10068
Format
application:pdf
Language
en
Collection
UMBC Theses and Dissertations
Rights Statement
This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu.
Source
Piekarski_umbc_0434M_10068.pdf
Access Rights
Access limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.
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